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  CHITON and CHITOSAN 䤵Թ ⵫ҹ      


CHITON and CHITOSAN were happened together with the lives in this world. Both are co-polymers 
in mixed Carbohydrates, included the derivative of Nitrogen-Glucose combination cat-ion molecules. 
CHITIN is the nature organic compound, insoluble in water and general organic solvents. CHITOSAN 
can solves in various organic acids, can be able to form gel,granule,fiber and surface coating. 
They protect and make strength to lives' cell-wall for their functions. We can found them in 
hard-shelled of shellfish which have many profits for plants,animals,and humanity like these ; 
1.Activate reaction for cell's working 
2.Enhance reaction for immunity 
3.Disinfect bacteria and mold 
4.Molecular separation reaction 

In addition, they can also apply in various products as the following 

1) Cosmetics; in shampoo, hair treatment, lotion,face powder, etc 
2) Microbe defending products; the results of experimentation showed that The concentration of 
     CHITOSAN 0.02% was able to inhibit the E-Coli in food and the growth of plants destroyer similarly. 
3) Dietic foods; CHITOSAN consumption can reduce the cholesterol content in blood. There are 
     manufacturing of cookies and ready-make noodles with CHITOSAN using for diet in Japan.
     In Thailand,there are the CHITOSAN capsule products according to decrease cholesterol and 
    weight control. 
4) CHITOSAN can sediment and treat waste water by precipitation because of their cat-ion 
     characteristic molecules. 
5) Using CHITOSAN in bandage of burn and scale 
6) Utilizing in agriculture as soil improvement grain coating, root activation, strength increasing, 
    bacteria virus and mold repression and pesticides. 


䤵Թ-⵫ҹ
»ա͹Թѡ "䤵Թ-⵫ҹ" ٻͧŴǹ Ѻзҹ͹
ö´ѡѺѹҡ÷Ѻзҹ ҧ ͡ҡѧö´ѡѺ˹ѡա

ѡ "䤵Թ" ѹ
䤵Թ 繾ҾҡѹѺͧͧš 觾ҡҵ ͨоٻͧûСͺԧ͹
䤵Թ-õչ (ͧ͡ŧ) 觹͡ҡо͡лǹѧҡͧ͡ŧ͹ ѧ
ͧ ʵ ͡ŧ ᡹ͧ֡ оع ʹǷ

ŷ: ⵫ҹ ͹ؾѹ¹Ӣͧ䤵Թ öʡѴҡͧ͡駢Ҵҧ 駡 
ͻ (1, 2, 3, 6, 7, 10, 13, 20, 24) աԨ·ҧԹԡԷҡ 17 ն֧⵫ҹŴ˹ѡҵ
() ͷ״ 㹡÷ӤҴ ¨Ҷ֧Ѩغѹ (21) ⵫ҹդسѵѵ
㹡ôٴѺѹ ҺѹþɺҧԴ ͷӨѴ¢ ⵫ҹ١ҧҧҧصˡ 
ͧҧ 駼Եѳ ÷ͧͧҹ (Han L. K.) ͹ҹͧ (1999) 
ç¹ᾷ㹻ȭ蹪 ⵫ҹͧѹͧ˹ѡ ͧѹѹʹ٧ Сѹ
㹵ѺҡѹͧҨҡú÷ѹ٧ ա÷ͧӡººâѺѹ͡ҡҧ Фسѵ
㹡Ŵ˹ѡͧèҡתѡҡªԴѺ⵫ҹ Żҡ⵫ҹŴ˹͡蹷 (19) 
§صˡ⵫ҹѧ纺ҴʹҴ 
ѡԷʵҧҹѴ⵫ҹ˹㹡˹ҷ ͷѡѹ ѧѹ ٴ (functional food) (6)


䤵Թ-⵫ҹ ջªúҧ
㹷ҧᾷ
䤵ԹشԴõ͵ҹҡҧ ռŢҧ§ѹ·ѧԭͧԹջª
ͤա 䤵Թ-⵫ҹѺʹҧҡѺþѲ㹷ҧᾷҧҧҧ  
ԭͧẤآҾ ͵ҹ ŴþѺ駡ԭͧẤ
ѹҧͫ 
ͧҡ 䤵Թ-⵫ҹ÷ҡҵ öѺҧ ҡ֡㹵ҧ ö
ѵ ͧҡ͹ªԴö ͡ҡ 䤵Թ-⵫ҹѧöѺ駡ԭͧŪվҧ
Դ ҡʹյҧ ͧ 䤵Թ-⵫ҹ ֧١ҹҧᾷ ѧҧ仹
-Wound-healing ointments 
-Surgical sutures 
-Orthopaedics 
-Drug delivery vehicles 
-Anticholesterol and fat bindings 
-Skin treatments 
-Wound dressings 
-Dentistry 
-Tranportation of cells 
-Ophthalmology 

çԨ¾Ѳ䤵Թ-⵫ҹѺѡŢͧٹ ѧԹ ͧ 㹼¨ҡغѵ˵
͹ǡ·Ҵعçҡѡͧҡ繡÷ͧ㹢鹵 ҡ÷ͧա ѡʺͧҴ 
Ҵ䤵Թ-⵫ҹöʴ ѺԴѡŷ öŴҡ纻Ǵͧŧ 
Ӽ˹ѧЪºҤءҹѺ١ ͹ǡ ;ǡʺغѵ˵ط֡ 
ҹᾷѪԷ 䤵Թ ⵫ҹ 㹡ѡҺҴ 㹡ѡ żҵѴ 觨Ъ
Ǣ ӼԵѳ蹻Դ 觢ʹբͧѹ µҧ ж١ٴѺҧ ҧ
ԡҵ͵ҹҡҧ Źµ ͧҡդسѵ͡ਹҹ͡ Դҡ
᤻źè ûͧѹõС͹ͧʹ 繵ǨѺеС͹ʹ Եѧ 蹼ѧ 
Ŵ شѹ㹴ҹѹ 

㹡ҧд١ пѹ
ҡä鹤ҢͧѡԷʵ쾺⵫ҹöеԴҧд١·ͧҡеعѢ

ºӺѴ 
ջªµ֧͹㹡÷ӼԵѳط öѺͧǹ ШѺѺеͧ˹ѡ

Ըաѡä 
դسѵԷ繤͹硵Ź ʴط᷹Ш ѡäҧաԴҡФͧ

ͧѵ§ 
Ѻѵ캡 ջª㹡ẤкҧԹ Ŵҡ÷ͧ

ҧҹɵ 
ͺǼżԵҧɵ״ءѡ лͧѹŧѴԹ
⵫ҹö͵繿ҧ ա ͺ״ءѡҼżԵҧɵ紾ѹ ѧ
ù͹ؾѹͧ䤵Թ⵫ҹõ͵ҹ ẤºҧԴ ѹöӧҹҧҧҧ
  Ѻä⤹Ҩҡ ä͹á ä 

䤵Թ-⵫ҹöŧѵ캡 ء ҳẤ·繻ª
㹷ҧԹ Ŵҡ÷ͧ¢ͧѵ Ŵѵҡõ¢ͧѵ͹ѹͧҨҡõԴẤªԴ
㹷ҧԹ 


Ŵ˹ѡ 
Шغǡͧ⵫ҹдѡѺôѹ ФŷջШźШж١ Ѻ͡ҾѺѹǹԹ

ҧҹ 
¤سѵԷ¹ ը֧ѲҹҷӼԵѳا д鹼 տѹ ͧҧ 
੾йͧҧǹͧôҵ AHA ¡е˹ѧش͡ ҧ
͹觢

䤵Թ-⵫ҹöŴǹ شʹҧҡ 䤵Թ⵫ҹ Шغǡѹ
ͧ⵫ҹ 繷֧ٴҡͧҡôѹ ФŷջШź ѧҵǵ˵آͧǹ 2  
еԴᨡѺ⵫ҹ Фö䤵Թ-⵫ҹ֧١Ѻ͡Ҿ Ѻب·դ
ѹǹԹ͡Ҵ 
⵫ҹջШغǡҧͷѹöСѺШźͧ˹ѧ鹼ҧ ֧١ͧҧ
ǹͧô ҵԷҤ鹪͡ѹҡôſδ͡ AHA 䧤Ѻ ôǡСе˹ѧش͡ 
ҧ Ǥس͹ ǹ㹡úا鹼 ⵫ҹС͵繿ͺ鹼 鹼Ҿ
§ 
صˡͧҧ ⵫ҹ١ͨشʧҧ ˹㹤 ǹ
Ū Ф¹ ǹм ǴФѺҾ ͧҡդسѵ 
˹״ Сͺ ͪ纤 鹼 ѷ㹻 кѷ⵫ҹ
ǹСͺ˹ º աù⵫ҹҧ˹ ͡ѡ
ҴŴѹ˹ 

ѲҼԵѳԵõǴ 
¹ҼѺʵԡ ͪö ͡ҡѧҷ繿÷öѺзҹ
ѹ

⵫ҹشʹѵԴ Ҩҡ෤աҡͧ繻ª 繷ҧ͡շ駵еǴ 
㹡èѴ͡ҡ ١駨ҡصˡѵ ҷӤѭҧҹǴͧ⵫ҹ ѹ͡
ӺѴӷ  

͡ҡúӺѴ ⵫ҹѧդö㹡èѺѺͧǹ ШѺѺеͧ ˹ѡ
աù仨ѺѺáѹѧҧ ǹèѺѺҺѹ 䡡èѺ ѺèѺѺ
ѹ㹷ҧԹ 

ҧҹ觷 
ͺ¼Ŵ˧СѺ еҹҹ Ấա
صˡ д 觷 ա⵫ҹ Ҫкèط㹸ҵ ӿ÷ö
Ѻзҹ 㹡üԵҷյԴҹ 㹡кǹüԵд դسѵԷҧҾ٧ ҹ͡éաҴ 
ͼԵдɷѺ֡͡þͧäسҾ٧ 

ҧҹ觾 
״ء͡Ӥѭ ·дդسѵ˹ ç ͡éաҴ ЫѺ֡

䤵Թ-⵫ҹ ÷öһءªҡ ǹͧ ùѺзҹ
Ŵǹ բͤѧ㹡óշѺзҹҨ Դҡ ôӵҡ  
ҡèдբ Ѻǡ÷ ˭ԧդ ˭ԧصèк



䤵Թ-⵫ҹ Ȩҡҵ
;ٴ֧䤵Թ 觷سҹ֧֡ѹѺá ͤǹ Ҥس˭ԧФس·蹵¹¨¤
ѧ ͧԵѳ䤵Թ-⵫ҹ ͡ҡЪ¤Ǻ˹ѡ 
䤵ԹѧþسաþѴྷ¡᷺к· 駴ѡѺҺѹ˹ѡ
آҾ ǹСͺͧͧҧ 

䤵Թ
䤵Թ繾ҾԴ˹觷ҵҧä ͧСͺçҧҧ ͧժԵҡ
ªԴ 䤵Թ繾ҾҡѹѺͧͧš ͧҡ䤵Թ繾辺㹸ҵ Ҩ֧ѡ䤵Թ
ٻ ûСͺԧ͹Ѻ 

䤵ԹûСͺǡõǡѺ ٻҧͧ䤵Թ ѡɳФ١Фӷ
СͺҨҡ ӵš ժ -ЫԷš⤫չ(N-acetylglucosamine) 

䤵Թ-⵫ҹ 觾ç
;ٴ֧䤵Թ աӷѡоǧҴ¤ ⵫ҹ ⵫ҹ͹ؾѹ˹觢ͧ䤵Թ ٻҧ˹ҵҢͧѹ¤
Ѻ䤵Թ ⵫ҹҡԡҡô֧ǹ¡ ЫԷ (acetyl group) ͧ䤵Թ͡ ¡ ԡҴЫԷŪѹ 
(deacetylation) ҡšǢͧ䤵Թ-ЫԷš⤫չ ١ŧ ⤫չ 
(glucosamine) ҹ ҡ¡䤵Թ¹⵫ҹ 

仢ͧЫԷ ⵫ҹǹͧšŷͤտ оз ԡҧͧ  
¡ (-NH2) ç͹Ƿ 2 š (CH2OH) ç͹Ƿ 6 š͹Ƿ 3 
ҡӻԡҹͧ⵫ҹ͡è ǧ 

䤵Թ-⵫ҹӧҹҧ
䤵Թ-⵫ҹзӧҹ繵ҧС͹еǵС͹ ҧС͹Сеɢͧ·ǹ 㹹Դ
ѹ繡͹ ˭ о˭ҡԹ絡繵С͹ŧ ǹǵС͹ зӧҹ ѹͨ仨ѺѺ
ǹ㹹ǵС͹ŧ -⵫ҹз˹ҷͧẺ 觷ͧҡ⹷öᵡ
Шغǡҡ ֧ǡШźҧõչ ôѹ (ҧ) ͧСѺШغǡͧ
⵫ҹ ǹ˹ѡ繻Шغǡ ШѺѺ硵͹ҡਹ⹢ͧ⵫ҹԴѹ
¡ ѹԧ͹ Шҡ÷ͧ⵫ҹöѺѺ˹ѡ㹹 աЫԷ
ͧ䤵Թ 


ҡ͢Ҵ: 
⵫ҹè繵ҧ ͨоٴѹ١⵫ҹѺ÷ҧͧ 
⵫ҹ繵Ŵ˹ѡǹСͺͧÿѧѹſٴ صˡ
ͧҧ բ׹ѹ֧âҴ⵫ҹ


ҴѺзҹ: 
㹢йѧաá˹ҴѺзҹ ͻҳйӵѹ (RDA) ͧ⵫ҹҧ͹ 
ҡ֡¡óժ⵫ҹ 8 (⵫ҹ᤻ŢҴ 250 ԡӹǹ 8 紵ѹ ͢Ҵ᤻ 
500 ԡӹǹ 4 紵ѹ) öٴѺѹ 10 СӨѴ͡ҡҧ仡Ѻͧ (21)


Ţҧ§: 
֧Ѩغѹѧҡ§ҹ֧ѭçͧ⵫ҹҧ 
͡ҡ֡ҴҹԷҢͧ⵫ҹѧ⵫ҹդ繾ɵա (11, 23)


ԡҡѺ: 
ķ㹡âѺѹ͡ҡҧ¢ͧ⵫ҹҧչӤѭѺԵԹ (2, 4) 
áԹ㹻ҳҡԴҴ繡ŴôٴѺͧŴдѺԵԹ㹹ʹ (5)


͡ҧԧ: 
1. Deuchi K., Kanauchi O., Imasato Y., and Kobayashi E. Decreasing Effect of Chitosan on the Apparent Fat Digestibility 
    by Rats Fed on a High-fat Diet. Biosci. Biotech. Biochem., 58(9), 1994: 1613-1616. 
2. Kanauchi O., Deuchi K., Imasato Y., and Kobayashi E. Increasing Effect of a Chitosan and Ascorbic Acid Mixture on 
    Fecal Dietary Fat Excretion. Biosci. Biotech. Biochem., 58(9), 1994: 1617-1620. 
3. Deuchi K., Kanauchi O., Imasato Y., and Kobayashi E. Effect of the Viscosity or Deacetylation Degree of Chitosan on 
    Fecal Fat Excreted from Rats Fed on High-fat Diet. Biosci. Biotech. Biochem., 59(5), 1995: 781-785. 
4. Kanauchi O., et.al. Mechanism for the Inhibition of Fat Digestion by Chitosan and for the Synergistic Effect of Ascorbate. 
    Biosci. Biotech. Biochem., 59(5), 1995: 786-790. 
5. Deuchi K., Kanauchi O., Shizukuishi M., Kobayashi E. Continuous and Massive Intake of Chitosan Affects Mineral and 
    Fat-soluble Vitamin Status in Rats Fed on a High-fat Diet. Biosci. Biotech. Biochem., 59(7), 1995: 1211-1216. 
6. Knorr D. Functional Properties of Chitin and Chitosan. J. Food. Sci., Vol.47, 1982: 593-595. 
7. LEHOUX J. and Gordin F. Some Effects of Chitosan on Liver Function in the Rat. Endocrinology., Vol.132 No.3, 1993: 1078-1084. 
8. Okuyama K., Noguchi K. and Miyazawa T. Molecular and Crystal Structure of Hydrated Chitosan. Macromolecules, 
    30; 1997: 5849-5855. 
9. Ikeda I, Tomari Y., and Sugano M. Interrelated Effects of Dietary Fiber and Fat on Lymphatic Cholesterol and Triglyceride 
    Absorption in Rat. J. Nutr. 119; 1989: 1383-1387. 
10. Knorr D. Dye Binding Properties of Chitin and Chitosan. J. Food Sci., Vol.48, 1983: 36, 37, 41. 
11. Knorr D. Functional Properties of Chitin and Chitosan. J. Food Sci., Vol. 47, 1982: 593-595. 
12. Ebihara K. and Schneeman B. O. Interaction of Bile Acids, Phospholipids, Cholesterol and Triglyceride with Dietary Fiber 
      in the Small Intestine of Rate. J. Nutr., Vol.119, 1989: 1100-1106. 
13. Vahouny G. V. et.al. Comparative effects of chitosan and cholestyramine on lymphatic absorption of lipids in the rat. 
      J. Clin. Nutr., Vol. 38, 1983: 278-284. 
14. Vahouny G. V. et.al. Dietary Fiber and intestinal adaptation: effects on lipid absorption and lymphatic transport in the rat. 
      J. Clin. Nutr., Vol. 47, 1988: 201-6. 
15. Razdan A. and Pettersson D. Effect of chitin and chitosan on nutrient digestibility and plasma lipid concentration in broiler chickens. 
      J. Nutrition, Vol.72, 1994: 277-288. 
16. Razdan A. and Pettersson D. Hypolipidaemic, gastrointestinal and related responses of broiler chickens to chitosans of 
      different viscosity. J. Nutrition, Vol. 76, 1996: 387-397. 
17. Razdan A., Pettersson D. and Pettersson J. Broiler chicken body weights, feed intakes, plasma lipid and small-intestinal bile acid
      concentrations in response to feeding of chitosan and pectin. J. Nutrition., Vol. 78, 1997: 283-291. 
18. Sugano M. et.al. Anovel use of chitosan as a hypocholesterolemic agent in rats. Am J. Clin. Nutr., Vol. 33, 1980: 787-793. 
19. Stasse-Wolthuis M. et.al. Influence of dietary fiber from vegetables and fruits, bran or citrus pectin on serum lipids, fecal lipids, 
      and colonic function. Am J. Clin. Nutr., Vol. 33, 1980: 1745-1756. 
20. Kay R. M. and Truswell A. S. Effect of citrus pectin on blood lipids and fecal steroid excretion in man. J. Clin. Nutr., Vol. 30, 1977:171-175. 
21. Chitosan. In: Clinical Studies Compendium. 
22. Fabulous Fiber In: In The Kitchen, Energy Times. June 1998: 20. 
23. Arai K., Kinumaki T., and Fugita T. On the toxicity of chitosan. Bull. Toka Regional Fisheries Res. Lab.No.56, 1968: 89. 
24. Shepherd R., Reader S. and Falshaw A. Chitosan functional properties. Glycoconj J. Jun 1997; 14(4): 535-42. 
25. Han L.K., Kimura Y. and Okuda H. Reduction of fat storage during chitin-chitosan treatment in mice fed a high-fat diet. Biosci 
      Biotechnol Biochem. Feb 1999; 23(2): 174-9. 
26. Lee J.K., Kim Su and Kim J.H. Modification of chitosan to improve its hypocholesterolemic capacity. Biosci Biotechnol Biochem. 
      May 1999; 63(5): 833-9. 


1.  
2. ٹ෤ʴ觪ҵ 
ӹѡҹѲԷʵ෤觪ҵ 


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